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Mouse anti-TfR Monoclonal Antibody [BLGM046]

bethyl
Bethyl Laboratories Catalog #
Target:
TfR
Reactivity:
Human
Applications:
IHC
Host:
Mouse
Clonality:
Monoclonal
Clone:
BLGM046
Format:
Whole IgG
Isotype:
IgG1, kappa
Conjugate:
Unconjugated
Purity:
Purified
100 µl

20 µl

$136.00 $516.00
Qty:
Bulk Request

Product Details

Specifications

Reactivity
Human
Antigen Species
Human
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline with 1% BSA and <0.1% Sodium Azide
Request Formulation Change
Country of Origin
USA

Additional Product Information

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor (TR) into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P02786].

7037
TFRC
transferrin receptor
P02786
Transferrin receptor protein 1

Alternate Names

CD antigen CD71;CD71;IMD46;p90;T9;TFR;TFR1;TR;transferrin receptor protein 1;TRFR