-
An end-to-end staining and analysis pipeline to identify immune cell infiltrates in oral cancer by multiplex immunohistochemistryWhitepaperThe ability to probe the tumor microenvironment (TME) at the single cell level is important for understanding of interactions between tumors and immune cells, particularly whether immune cells have infiltrated into tumor nests, and with regards to the presence or absence of immune checkpoint markers. The ability to interrogate these questions relies on the ability to assess multiple biomarkers simultaneously for cell phenotyping in their spatial context. Here we demonstrate rapid design and optimization of a panel of antibodies for multiplexed immunohistochemical staining of a series of oral cancer tumor samples.
-
Multiplex analysis of the tumor microenvironmentWebinarIn this animated video, learn how spatial biology is used to interrogate the tumor microenvironment. You'll learn about key immune cell populations that are found within the tumor microenvironment and how spatial biology techniques can be used for biomarker identification and patient stratification.
-
Overcoming Challenges in CRISPR ApplicationsArticleIdeas for troubleshooting CRISPR experiments include addressing off-target effects, increasing delivery efficiency, avoiding immune responses, and improving enzyme stability.
-
Infographic: Multiplex immunofluorescence techniques explainedInfographicMultiplex immunohistochemistry-immunofluorescence (mIHC/mIF) techniques enable the simultaneous detection of multiple proteins of interest in a single sample. This provides numerous benefits in the examination of different tissues, such as a tumor biopsy. Learn about the benefits of mIHC/mIF experimental approaches and key spatial biology techniques. such as tyramide signal amplification (TSA) and cyclic immunofluorescence.
-
Podcast: Mitochondria, the immune system and cancer- discovering new insights with spatial technologiesPodcastIn this podcast, produced in collaboration with BioTechniques, we delve into the relationship between mitochondria, inflammation and cancer, discussing the new techniques that are bearing fruit in this field, such as spatial analysis. Guest speaker: Dr. Phillip West, formerly at Texas A&M Medicine and now at The Jackson Laboratory.
X
By clicking “Acknowledge”, you consent to our website's use of cookies to give you the most relevant experience by remembering your preferences and to analyze our website traffic.
Read our Privacy Policy