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Understanding Neuronal Network Activity in Developmental and Epileptic Encephalopathy 9October 18, 2024ArticleDevelopmental and epileptic encephalopathy 9 is a neurodevelopmental disorder caused by a mutation in PCDH19. Because disease only occurs in heterozygous PCDH19 individuals, scientists developed a mosaic mouse model where some cells express PCDH19 and others do not. This model helped them understand that PCDH19-negative neurons are hyperexcitable in a DEE9 mouse model and how the brain responds as a result.