Rabbit anti-ROR1 Recombinant Monoclonal Antibody [BLR390P]
Product Details
Specifications
Request Formulation Change Phosphate Buffered Saline (PBS) with 0.09% Sodium Azide, BSA-Free
Request Formulation Change
Immunogen was a recombinant protein representing human receptor tyrosine kinase-like orphan receptor 1 (aka ROR1, residues 1-403, NP_005003.2).
Additional Product Information
ROR1 encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. ROR is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. ROR1 is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of ROR1 is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [taken from NCBI Entrez Gene (Gene ID:4919)]
Alternate Names
dJ537F10.1;inactive tyrosine-protein kinase transmembrane receptor ROR1;neurotrophic tyrosine kinase, receptor-related 1;NTRKR1
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (S100-020) added to the blocking buffer.