Rabbit anti-MSH6 Recombinant Monoclonal Antibody [BLR117H]
Product Details
Specifications
Request Formulation Change Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
Request Formulation Change
Immunogen was a peptide representing a region between residue 1310 and the C-terminus (residue 1360) of human DNA mismatch repair protein Msh6 using the numbering given in entry NP_000170.1 (Gene ID 2956).
Additional Product Information
MSH6 is a component of the DNA mismatch repair (MMR) system that functions to recognize base-base mismatches and framshift mispairs. MSH6 forms a heterodimer with MSH2 and is also part of the BRCA1-associated genome surveillance complex (BASC). Mutations in MSH6 have been linked to endometrial carcinoma.
Alternate Names
DNA mismatch repair protein Msh6;G/T mismatch-binding protein;GTBP;GTMBP;hMSH6;HNPCC5;HSAP;mutS protein homolog 6;mutS-alpha 160 kDa subunit;p160;sperm-associated protein
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.